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KMID : 0377619720220050529
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Korean Jungang Medical Journal
1972 Volume.22 No. 5 p.529 ~ p.532
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Effect of Complement on in Vibrio Vibriocidal Action of Cholera Antiserum
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Abstract
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As one of the steps of investigating the particular vibriocidal mechanism of cholera antiserum, normal and immune sera were inactivated by heating at 56°C for 30 min. and tested as to their bactericidal action with or without the addition of complement.
Regardless of serum kinds, all of the inactivated sera did not show any bactericidal activity without complement addition. When complement was added, only immune sera restored more or less the bactericidal activity as expected. The pattern of recovery, however, was noticeably contrasting between brucella and cholera antisera. In the former, brucellacidal activity was enhanced as the serum was diluted, while in the latter the acceleration was noticed only at the undiluted portion of serum.
These results suggest that the difference of serum bactericidal activity between brucella and cholera is not due to the specific change of immune serum, but to the particular quantitative balance of complement and antibodies against an organism.
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KEYWORD
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